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Inventi Impact: Med Chem

Articles

  • Inventi:pmc/29999/19
    New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015
    Research 2019 : October - December
    Xiaoyan Pang, Guodi Cai, Xiuping Lin, Limbadri Salendra, Xuefeng Zhou, Bin Yang, Junjian Wang, Junfeng Wang, Shihai Xu, Yonghong Liu

    The sponge-derived fungus Penicillium sp. SCSIO41015 cultured on solid rice medium\nyielded twenty-one compounds (1-21), including two new alkaloids (1 and 2) and one new pyrone\nderivative (3). Their structures were elucidated by analysis of 1D/2DNMRdata and HR-ESI-MS. Their\nabsolute configurations were established by single-crystal X-ray diffraction analysis and comparison\nof the experimental with reported specific rotation values. Compound 16 exhibited selective cytotoxic\nactivity against the human gastric cancer cells MGC803, with IC^50 value of 5.19 microM. Compounds 9\nand 18 showed weak antibacterial activity against Staphylococcus aureus and Acinetobacter baumannii,\nrespectively, both with MIC values of 57 microg/mL. Furthermore, compound 16 displayed potent\nantibacterial activity against S. aureus with an MIC value of 3.75 microg/mL.

    How to Cite this Article
    Attribution/ CC Compliant Citation: Pang, Xiaoyan, et al. \"New Alkaloids and Polyketides from the Marine Sponge-Derived Fungus Penicillium sp. SCSIO41015.\" Marine Drugs 17.7 (2019): 398.\nhttps://doi:10.3390/md17070398\nhttp://creativecommons.org/licenses/by/4.0/ \n\nSome formatting elements, header, footer, logos, dates and pagination were modified while adapting this article.
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